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No, not really. Many costs of an office are "fixed" -- that is, since you can't rent your building half time or hire nurses half time, it might be hard to cover overhead. Working in a partnership means your partners will have expectations for you. And working in an academic center carries expectations as well.
Besides, most folks here aren't talking about practice, they're talking about residency. Those hours are definitely not up to you; and even if they were, you wouldn't be able to live on less pay anyway.
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