Honestly, they are ALL very difficult to get into. I do believe it is a 'crapshoot' to some extent. I got interviews at Drexel and Temple, and straight rejected from GWU and Rice, including others. One of my acquaintances got straight rejected from Drexel and Temple, and interviews at GWU and Rice. So really speaking, they are ALL (if not all, then almost all) VERY hard to get into (at the same if not higher level of difficult as Ivy League schools, I believe)
Idk if its just me, but I have had more success getting interviews in-state (Pennsylvania). The colleges dont "bias" towards in-state applicants (like NEUCOM, UMKC, and other programs), but some of my accomplishments (like Pennsylvania's Governor School for Healthcare) may not be understood very well by colleges outside of Pennsylvania.
Just apply to as many as you can if you think you have the stats / ECs to get in, and write the best essays you can, then just hope and pray you get accepted to at least 1 of the programs you applied to.