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I too had to take the Accutane route. I'm cursed, as far as acne goes, on my mom's side of the family. Even after two rounds of taking Accutane (well, I took Amnesteem, the generic)I still get a few places pop up here and there, mostly when I've had a rough week or something.
Accutane is a really high-maintenance drug. I was at the drug store buying Blistex about once a week for my chapped lips and my nose sometimes bled like a faucet (swabbing it with vasoline in the morning would cut down on that, though). Also, I had to have my blood drawn once a month to check my lipid levels. For females, they have to take birth control and take a preg. test once a month due to the severe birth defects that can result from getting pregnant while on Accutane.
As far as depression goes...yeah. I never admitted it to the derm (in fear she'd take me off the Acc.), but I did experience some (but girl trouble around the time didn't really help things...heh...).
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