I always thought that the tendency of a school to exhibit the symptoms of Tufts Syndrome was best correlated to the weight it places on demonstrated interest. Perhaps there are schools where demonstrated interest doesn't matter and are still, somehow, afflicted by the sickness.
A school afflicted with Tufts Syndrome is a college that, while not being a reach-for-anyone college, waitlists or rejects "overqualified" students, in an attempt to protect yield.
Are there other factors to take in account when assessing the vulnerability of a school to the TS? I know that most non-holistic schools are not afflicted.