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Some Catholic high schools have special connections with certain catholic colleges. Here, there's a school named St Xavier which I believe sends a disproportionately large number of students to the local (Jesuit) Xavier University. If a lot of students at your school are applying to a school like that, no problem. If a lot of students from your school are applying to Georgetown and Notre Dame and other selective Catholic/Jesuit schools, and you don't go to connected high schools (eg: Georgetown Visitation Preparatory School), then you might be a slight disadvantage, but these schools are so selective anyway that it won't make a huge difference.
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