I really enjoyed the 331 lectures. Quizzes every week really keep you on top of the material, but I didn't feel overwhelmed by them. My friends who took the autotutorial were consumed by the class and I really didn't think it was worth it. 331 was one of my favorite classes. Bik Tye's lecture was super boring, but for some reason biochem came naturally to me, so I rarely went to lecture or just read the paper during lecture and got an A without much effort, just a long cramming session 2 days before the exams. I do not regret taking the lectures. My friend fell behind in the autotutorial and got an F!
PS I also enrolled in 334, the computer graphics in molecular bio 1 credit class and thought it was easy/fun as well.