Loyola is closer to Evanston so naturally, the lake shore campus isn't very near the part of the city you're talking about, but, to me, Chicago is typically all city so I feel like its in the city. They have another campus, though. Downtown.
It takes about 20 minutes by EL. The station is at the entrance of campus, really easy and you a transit pass as part of all the tuition and fees you pay. There is also a shuttle between the two campuses