11-03-2009, 03:01 PM
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A little research information: Quote:
Pattern of use and subjective effects of Salvia divinorum among recreational users
Débora Gonzáleza, Jordi Ribab, José Carlos Bousoa, Gregorio Gómez-Jaraboa and Manel J. Barbanojb, ,
aCátedra de la Fundación Cultural Fórum Filatélico de Psicobiología y Discapacidad, Departamento de Psicología Biológica y de la Salud, Facultad de Psicología, Universidad Autónoma de Madrid, Madrid, Spain
bCentre d’Investigació de Medicaments, Institut de Recerca, Servei de Farmacologia Clínica, Hospital de la Santa Creu i Sant Pau, Departament de Farmacologia i Terapèutica, Universitat Autònoma de Barcelona, Barcelona, Spain
Received 9 March 2006; revised 10 April 2006; accepted 12 April 2006. Available online 23 May 2006.
Abstract
Backgroud
Salvia divinorum is a member of the Lamiaceae family and contains the psychotropic diterpene and kappa-opioid receptor agonist salvinorin-A. Originally a shamanic inebriant used by the Mexican Mazatec Indians, the plant and its preparations are becoming increasingly popular among non-traditional users.
Methods
Demographic data and information on pattern of use and subjective effects were obtained by means of self-report questionnaires from a sample of 32 recreational users of salvia and other psychedelics.
Results
Involvement with salvia appeared to be a recent phenomenon. Smoking the extract was the preferred form of administration. Subjective effects were described as intense but short-lived, appearing in less than 1 min and lasting 15 min or less. They included psychedelic-like changes in visual perception, mood and somatic sensations, and importantly, a highly modified perception of external reality and the self, leading to a decreased ability to interact with oneself or with one's surroundings.
Conclusions
Although some aspects of the subjective effects reported were similar to high doses of classical psychedelics with serotonin-2A receptor agonist activity, the intense derealization and impairment reported appear to be a characteristic of salvia. The observed simultaneous high scores on the LSD and PCAG subscales of the Addiction Research Center Inventory (ARCI) have been previously reported for other kappa-opioid agonists, and support kappa receptor activation as the probable pharmacologic mechanism underlying the modified state of awareness induced by salvia.
Keywords: Salvia divinorum; Pattern of use; Subjective effects; Retrospective assessment
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