Elizabeth...
We are from Southern California. We moved to Alabama with my H's job. It is not a "big adjustment" at all to live or go to school in Alabama. Many kids who go to Alabama are not "native" Alabamians even tho it may now be their "home state". There are thousands of transplants living here now (because of high tech jobs), and many of their kids go to UA.
Tuscaloosa is a nice, normal city. It is growing with the school. Many new shops, restaurants, etc. Therefore, many opportunities for part-time jobs for students.
As feeno noted, the people are very friendly and welcoming.