DO NOT try to go to the La Cienega store. It's FAR (like, probably 30 minutes without traffic if you take Wilshire to La Cienega).
The store on La Brea is only about 4 miles, but it'll take anywhere from 15-40 minutes to get there on Santa Monica or Sunset depending on the time of day.
The Culver City one is the same way, but I guess you could take the freeway so it might go faster (or not, again depending on the time of day).
I much prefer the La Brea one, personally. It's much, much bigger and much newer than the others. Plus I like the drive through W Hollywood much better than sitting on Sepulveda for a year. But that's just me.
Not the streets themselves. But the target on La Brea is on Santa Monica while the Target on La Cienega is alllllll the way down by the 405 and the airport.
The La Cienega one is not near the airport (though its ghetto), though the La Brea one is probably closer as long as you're not driving during peak times. WeHo and its major thoroughfares (Santa Monica, Sunset) practically stop during rush hour. Go to Culver City or La Brea.
The la cienega store is most definitely in the ghetto, and while not near the airport itself, it's definitely in that direction.
And the weho store IS the labrea store. Both streets suck during rush hour, but so does the freeway and sepulveda, so i guess the moral of the story is don't try to go to target during rush hour.