Are there any differences in costs? Run the numbers here: http://www.finaid.org/calculators/awardletteradvanced.phtml then talk the results over with whoever it is who is helping you pay for your education. What could you do with any savings?
Are there any differences in travel time/expense? Would you be able to get home more often if you chose one or another? Would your parents/friends/extended family be able to come visit more often at one or another? Do you want to be farther from home? closer to home? closer to possible part-time jobs or internship sites?