will antidepressant more likely help or make things more complicated?

Shrinkrap
Tue, 11 May 2010 01:40:48 +0000

While not the point of the article, it is a pretty good review of the literature on effect size.

[NEJM – Selective Publication of Antidepressant Trials and Its Influence on Apparent Efficacy](http://content.nejm.org/cgi/content/short/358/3/252)

" According to the published literature, it appeared that 94% of the trials conducted were positive. By contrast, the FDA analysis showed that 51% were positive. Separate meta-analyses of the FDA and journal data sets showed that the increase in effect size ranged from 11 to 69% for individual drugs and was 32% overall."