will antidepressant more likely help or make things more complicated?

Booted
Tue, 11 May 2010 02:26:38 +0000

While not the point of the article, it is a pretty good review of the literature on effect size.

NEJM – Selective Publication of Antidepressant Trials and Its Influence on Apparent Efficacy

" According to the published literature, it appeared that 94% of the trials conducted were positive. By contrast, the FDA analysis showed that 51% were positive. Separate meta-analyses of the FDA and journal data sets showed that the increase in effect size ranged from 11 to 69% for individual drugs and was 32% overall."





It so happens that these trails can be hand selected by the drug companies before submission and they mag gag any other scientific study funded by them as well.