Yes, there are certainly DE courses worth taking - just examine each option.
Our HS offers a second year Physics course as both AP Physics C and DE with University of Pittsburgh freshman Physics for Engineers.
A C or better will transfer to most colleges, whereas many of the schools my D was looking at required a 5 to place out of Freshman Physics. Almost all were a 4 or higher. It was a lot easier to take DE to get credit (though still more $$).
MVC, Linear, DiffEq are often only available in conjunction with a college.