Actually, it may be slightly less difficult if you aim for a major that exists but is less popular at the college, since (for example) JHU is flooded with pre-med and biomedical engineering applicants, Stanford is flooded with CS major applicants, Harvard is flooded with economics (pre-finance and consulting) applicants, etc… Of course, the application must be convincing that the less popular major is your true interest, not a Trojan Horse for application purposes while you intend to change major after enrolling.
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