We’ve moved several times with our dogs. As mentioned before there’s a big difference in how different hotels welcome/charge for dogs. We’ve paid more for a night’s stay for our dogs ($75 each) than for our own hotel room.
We currently have one smaller (22 lb) and one larger (55 lb) dog, and have a large soft-sided travel crate from Orvis that goes in the back of our SUV, where the dogs stay. I pack a canvas tote bag with all their stuff. I have a refillable water bottle, those collapsible travel dog bowls, a ziplock bag of kibble, and rolls of poop bags. I find the dogs don’t eat/drink a ton while traveling.
We stop at rest stops and take turns walking the dogs while we each other uses the rest rooms. For meals on the road, if the weather permits, we find fast food places that have outdoor seating. Otherwise, we’ve gone through drive-thrus and eaten in the car.
My dogs have been fine in the car, but it’s definitely more work and limiting than when traveling without them.