Am I bringing too much to college: 1 large luggage, 2 duffel bags, my guitar, and a laundry bag?

The number of bags seems OK. Now about contents Leave the detergent and fabric softener because they are universally available and will figure out how to leak or spill. Motion seems to cause lids to start opening.

Prescription medications go with you in a bag you can grab and go if necessary. That bag should also include a book to read for relaxation. If you had these things in a small bag, put the laptop and cord in it too. Alternatively, your laptop will smell good and slip and slide. Actually a computer bag will hold computer, book and meds.