<p>Well, I’ve only taken AP Chem and am taking AP Bio for my junior year (having taken Honors Bio during freshman year and gotten a high A). Naturally, I’ll be a bit biased in my statement here, but chem is by far the harder subject, although both require an immense amount of time. Whereas bio is purely memorization, chem requires actual understanding of the concepts and how/where to apply them. Nevertheless, take the class in the subject you’re strongest in. If you do end up self-studying chem, I recommend using Princeton Review’s prep book; read it thoroughly, and you’re guaranteed at least a 4. Good luck with whatever path you choose to take!</p>