AP Stats or AP Bio

@jollyjellyjojo, It’s really more about the balance of all your high school classes over time rather than one course vs another course.

Just make sure that you will be able to fit in (bare bones) Algebra 1 and 2, and geometry, and one class each of biology, chemistry and physics. After that, which math/science APs you take are your choice. The most selective colleges (if that happens to be your aim) will give more weight to Pre-Calc/calculus than statistics, especially if you will be on a STEM or economics track. If you are veering towards humanities or social sciences, statistics will be fine as long as you have a rigorous, well-balanced record overall.

Ideally, you should take one course each in all core courses, for all four years, so I don’t quite understand why you are choosing between a math and a science unless you are doubling up at the expense of another core subject (such as foreign language).