I would not assume rejection. There are many factors considered, and, as pointed out, the courses are not required. The admissions officers will view your daughter’s application in its entirety, considering the opportunities available to her at her school and how she took advantage of them and excelled in classes.
That said…
Their admitted student data show 85%+ of students taking calculus, 4 years FL, and the trifecta of bio/ chem/ physics. Since they publish that fact, it matters somewhat to them. But it matters in the aggregate, not for any one student per se.
Solely because those three things are highlighted by Wesleyan in their brochures, and Wesleyan was one of his top choices, my son took physics senior year! Ironically, he ended up not even applying to Wesleyan because he got into another college early decision. But he is enjoying the physics class, so it worked out well anyway!