My point is that they may discount your stellar grades at an uncompetitive high school to some degree because you weren’t able to perform at the same level in a college course. There is a lot of grade inflation right now in high schools, so your DE grade may matter because it can sometimes be hard to gauge an applicant’s true skill level when high schools give all high grades.
I am not saying this will be the case for sure, but it could be the perception, especially if combined with an ACT score that is below the expectations of the schools you mentioned. You have several hooks that will likely mitigate these issues, but it’s something to consider.