Can you take a break in the middle of college and pick it up again later?

Yes - Google it. Here’s Berkley, for example. http://ls-advise.berkeley.edu/registration/withdrawal.html and http://registrar.berkeley.edu/canwd.html

This is typical of most schools: If you notify them by whatever the deadline is before the semester starts, it’s usually not a problem to take time off. But each school has their own rules.

We know 4 students who decided to take time out for a year or more during college. All four were finishing their second years and three still hadn’t decided on a major or what they wanted to do professionally. One returned and has now finished and is a school teacher. The second found his major and ended up in a graduate program in his area of interest. A third left to join a start up and is doing so well professionally that he may never go back. A fourth is still figuring it out three years later - but he’s got a job he likes and is self-supporting, which doesn’t make him a ‘drop-out’ in my book (with the ‘loser’ connotation that goes with it.) Good outcomes for all four, because they figured out their paths, and didn’t blow lots of tuition dollars for their parents in the process. Yeah, their parents were very nervous - but trusting your kid is not a bad strategy in a situation like this. (As opposed dealing with to a kid who is failing academically, and/or seems to be having mental health and/or adjustment issues - an entirely different situation.)

Our D took shorter periods off during her college career, but that was to pursue academic interests elsewhere: Study abroad she organized herself in both cases because it was less expensive and less restrictive than goes with school-based programs - but I assume this isn’t what you are talking about.