Please go re-read @DadTwoGirls post. You need to learn more about these schools than just what their “strongest” programs are.
An easy example:
“Schools like Harvard or Yale where it’s easy to transfer between departments, i’d just apply to a weak major that’s inline with my Ec’s to boost my chances”.
Those schools don’t admit by major, and pretending to apply to what you think is a weak major is not going to boost your chances even a tiny bit.
Your chances will be best at the schools that are a good fit for you. Are you somebody who really loves the idea of the Columbia core? if so, why isn’t UChicago on your list? If you would be happy in the BME program at JHU, b/c you thrive in a pool of intensely motivated peers, would you really be as happy at Brown, which has students who are just as smart, but has a notably different vibe? If you aren’t sure you want to do business*, have you considered how you will fit in at Wharton?
*And if you want a hybrid science/business career, getting the science part first in UG, and the business part in PG works better than the other way around.