I see nothing listed under cost constraints. Does this mean that you are okay spending potentially at least US$800,000 and possibly a bit more by the time that your daughter gets her doctorate? Can you handle this without taking on any debt? This is of course well over C$1,000,000 if you convert to Canadian dollars.
It is of course possible to get an MD for a lot less if you have either Canadian citizenship or permanent residence and if you attend university in Canada. It is also possible to get an MD in Canada and then do your residency in the US. This is exactly what my former oncologist did (his oncology residency was done in the US after getting an MD in Canada).
Premed classes will be very challenging regardless of whether you get your bachelor’s degree in the US or in Canada. Both daughters had undergraduate majors that overlapped a lot with premed classes (and had many premed friends), but one got her bachelor’s in the US and one got her bachelor’s in Canada. Both have told me similar stories about challenging premed classes full of strong students, and tough exams. Both did however get into very good and appropriate graduate programs in the US.
Getting accepted directly to BS/MD programs in the US is a high reach for US citizens. It is going to be much more difficult as an international student. I think that it is also risky to get your bachelor’s degree in the US expecting to get into a US medical school as an international student. With straight A’s throughout high school, a lot of high A’s / A+'s, and 1550 SAT, and good ECs, you will get accepted to some very good universities in the US. They might not include Harvard or Stanford or any BS/MD program, but this is sufficient to get many acceptances. Gaining acceptance to very good universities for a bachelor’s degree will be the easy part. Then getting accepted to an MD or DO program as an international student can be tough.
My understanding is that students who start off in a BS/MD program have to maintain a sufficiently high GPA in the tough premed classes (or be kicked out of the MD part). Do not underestimate how tough these classes will be.
Regarding stories from daughters about premed classes, I recall one story about a friend who in high school had either a high A or an A+ in AP biology, and was bragging that this would make her better prepared to do well in “freshman year biology for biology majors” compared for example with my daughter who attended a high school which did not have AP classes. This bragging stopped abruptly after the first mid-term exam. The class was full of premed students who had been strong students in high school, and the class average on the first exam was in the mid 40’s. I took this as the professor doing a favor to students who thought they were premed but who were going to need to up their game considerably if they wanted to ever have any chance to attend medical school. Professors can make exams almost arbitrarily difficult if they want to do so. I do not think that schools that have a BS/MD program are going to have easier exams in their premed classes.
My recollection from back when I was a high school student in Canada is that a domestic Canadian student, with either Canadian citizenship or permanent residency, and with a 97% average across high school (or even the last 2 years of high school), plus 1550 SAT, could pretty much attend any university that they wanted to attend in Canada, get a very strong education, and pay a great deal less than what university costs in the US. I certainly knew students with somewhat lower high school GPAs who considered McGill to be a safety in-province (and they, or more precisely we, did get in), and same is true for some other people I know but swapping UBC for McGill.
I do not think that there is any safe path here that reliably leads to a doctorate. I think that strong students who are interested in medicine need to have some faith, pick an undergraduate university that is a good fit for them, plan to work very, very hard, and keep open the option of a plan B (which might or might not have anything to do with medicine). Also, anyone embarking on a path that involves 7 or 8 years of university needs to budget for 7 or 8 years of university.