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<p>Like @nhdmaniac said, as soon as possible. Honestly, if you can get everything in before the end of September, do it.</p>
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<p>Hard, but you’re coming with a solid background and strong academic presence, so it’ll be <em>less hard</em> for you. Engineering itself is very difficult, which is why any GPA >3.0 is considered good and any GPA >3.5 great, GPA >3.75 just incredible. Combining BioE with some of the premed requirements (like OChem) will be difficult, but I had friends do this exact path and one of them is at Stanford Med now, so anything is possible! </p>