My S was rejected from Columbia, 34 ACT, 4.0 UW, I it was higher weighted, 4s and 5s on APs, including Calc BC, National Merit Commended, team captain. At the info session, Columbia said that they could fill the class 7 times over with kids who can do the work. From our high school they admit athletes and especially outstanding female fencers.
You can always apply, but make sure to apply to safeties too. Good luck!