If you don’t have the background, training, and skills to perform a job, it’s unlikely you’ll be hired for it. But it’s certainly possible to have these skills independent of a specific college major - especially later in a career.
What type of “computer-orientated” (sic) job are you looking for?
Do you have a background and demonstrable experience in programming, algorithm design, SDLC, etc. that a software engineer, developer, etc., would need? If so, then your college degree wouldn’t matter much. But most entry-level folks get these experiences and knowledge through their undergraduate degree.
Data entry and similar jobs have lower skill/experience requirements but those aren’t the type of computer-related jobs with large growth potential.
Program management and similar roles in the industry are often filled by students with different majors. My firm recruits engineers from highly regarded schools - hiring talent that can later be taught specific skills - for analyst/PMO/etc. roles
(Fwiw, I worked for one of the world’s largest technology consulting firms. One of the best Partners I ever worked for had an undergraduate degree in History - so it’s possible.)