<p>OK, On cholesterol, the guy that I have found to be the most compelling is an MD lipidologist named Thomas Dayspring. He’s got a Jersey-style of explaining this stuff that is entertaining. He’s also interesting in that he is more than happy to jump right to high-dose statins with patiients, but ONLY if they have high risk profiles. On the other hand, he’s more than happy to go with diet and lifestyle when appropriate, even with patients who have “high cholesterol”.</p>
<p>His short YouTube version:</p>
<p>[Traditional</a> Cholesterol Testing vs. LDL Particle Number & Apo B, by Dr. Michael Richman, MD - YouTube](<a href=“- YouTube”>- YouTube)</p>
<p>His written version:</p>
<p><a href=“http://www.lipidcenter.com/pdf/Understanding_the_Entire_Lipid_Profile.pdf[/url]”>http://www.lipidcenter.com/pdf/Understanding_the_Entire_Lipid_Profile.pdf</a></p>
<p>His podcast version:</p>
<p>[585:</a> Lipidologist Dr. Thomas Dayspring Explains The Truth About Cholesterol | The Livin La Vida Low-Carb Show](<a href=“http://www.thelivinlowcarbshow.com/shownotes/6371/585-lipidologist-dr-thomas-dayspring-explains-the-truth-about-cholesterol/]585:”>http://www.thelivinlowcarbshow.com/shownotes/6371/585-lipidologist-dr-thomas-dayspring-explains-the-truth-about-cholesterol/)</p>
<p>Long video interview version:</p>
<p>[Michael</a> Andreula Interview With Lipidologist Dr. Thomas Dayspring - YouTube](<a href=“Michael Andreula Interview With Lipidologist Dr. Thomas Dayspring - YouTube”>Michael Andreula Interview With Lipidologist Dr. Thomas Dayspring - YouTube)
[Lipids:</a> Michael Andreula Interview With Lipidologist Dr. Thomas Dayspring - YouTube](<a href=“Lipids: Michael Andreula Interview With Lipidologist Dr. Thomas Dayspring - YouTube”>Lipids: Michael Andreula Interview With Lipidologist Dr. Thomas Dayspring - YouTube)</p>
<hr>
<p>On the testing, I’ve had both the NMR Particle Test and the VAP test. Both are $75 to $125 if you just walk in off the street or with an internet order. I had to pay for the NMR test (because I haven’t hit my deductable for the year). With the Blue Cross provider pricing, it was under $40. So, whatever cost over and above the plain jane cholesterol test is insignificant.</p>
<p>The NMR test gives all the standard info: total cholesterol, HDL cholesterol, triglycerides, and calculated LDL. In addition, it give the NUMBER of LDL particles, the number of HDL particles, the sizes of LDL and HDL particles, and an insulin resistance score.</p>
<p>In many (but not all) people, a high LDL cholesterol number will be a proxy for a large number of LDL particles (the real risk factor). So, for those people, a simple LDL test with a high reading will be an accurate picture of higher risk for coronary disease. But, a some people have high LDL with a small number of LDL particles. These people are not at risk of coronary disease. Conversely, some people have low LDL cholesterol and very high numbers of LDL particles. They are heart attacks waiting to happen. Tim Russert’s LDL was 60 on his last test before he died of massive heart attack. He was almost certainly in the group with a low LDL and large numbers of LDL particles (this is also the type 2 diabetes and metabolic syndrome profile).</p>
<p>I would personally not start any cholesterol medication until I had the NMR test and figured out where I stand on this whole particle count issue.</p>
<p>An alternative, that any doc can order, is an apoB test. ApoB is a protein molecule, one for every non-HDL particle in the blood. 95% of the apoB particles are LDL, so it’s a good substitute measure of LDL particle count.</p>
<p>The VAP test doesn’t give a particle count. It just gives the size of the LDL particles. This is sort of useful. For a given amount of LDL cholesterol, if you have small particles, you’ll probably have more particles. But, there are some genetic diseases where people have large number of massive large LDL particles. Without statins, those people die of heart attacks in their 20s.</p>
<p>It is becoming clear that, putting aside some fairly uncommon genetic issues, metabolic syndrome is a major heart disease risk. This is the same insulin resistance that is associated with type 2 diabetes, obesity, high blood pressure. The typical lipid profice of someone with metabolic syndrome is high triglycerides (over 100), low HDL, and a ton of small, dense LDL particles. This is what results in heart disease, even when the LDL number is low. This is also pretty easy to treat with diet – although not with the recommended low-fat diet. This is pure and simple an inability to properly metabolize carbohydrates. Cut sugar and carbs and this problem gets better fast.</p>
<p>This is an awesome six-part interview with Dayspring and Gary Taubes:</p>
<p>[Gary</a> Taubes & Dr Thomas Dayspring - YouTube](<a href=“http://www.youtube.com/playlist?list=PL0A01EBCE2711A5A5]Gary”>null - YouTube)</p>