It depends if its a requirement of your major or not, but generally talking to the dean or someone in a college can do the trick. You will likely be able to skip the class but not get credit for it, only be able to take higher level courses. I know one person who substituted discrete math in CS for Calculus 3.
Generally, if you take to the right people and be persistent and patient, Northeastern is pretty flexible with most things (does not apply to financial aid and merit scholarships for admission purposes, more so class requirements, double counting courses, substitutions, prereqs, coreqs, etc).