I agree with others that she shouldn’t take multivariable calculus in high school.
If she majors in neuroscience, it definitely won’t be required anyway. A bunch of engineering majors take (or retake) Calc 1 & 2 as freshmen, so she’d be ahead of the game even as an engineering major. Some engineering schools require a 5 to get credit for calc or as a prerequisite for the next course. That’s good because those majors have got to make sure they’re really firm on the math before moving on to the next course.