Unless you have a significant price difference and/or chasing miles on one particular airline, minimizing stops and duration time is usually at the top of the list of what most people would consider important in choosing a flight. I’m not sure what city you’re flying to/from, but the 2 most fearful things that come to my mind are possible missed connection(s), and having to get on a 20-seat puddle-hopper. I’d go with Frontier.