Time is money. These days whenever possible we fly direct- no plane changes or layovers if we can help it (we have one upcoming itinerary change in ICN and I am a bit concerned, but thats another story). Driving in Quebec, IIRC, is a PITA, and by the time one potentially pays for hotel parking (which can be pricey) and/or other parking for a rental car (cost of that??) , it adds up. Canada is my vote, OP, but fly direct into one of your 2 cities and don’t waste time and money driving from the US. The line to cross at the border could also be long and more wasted time. Just, no.
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