My D24 sounds very similar to yours (North Carolina resident, similar stats) and is also considering neuroscience leading to med school.
Our budget is also around $50K. We dropped UMD from consideration because it seemed very unlikely to meet that.
Virginia Tech will probably be right at the top of that 50K budget but it has a really nice neuroscience program with multiple options and not too far from home, so we will be applying and hoping for the best.
Arizona looks interesting and nice merit, but D24 is a no on the location.
Like your D, Wilmington is D24’s in state, likely most affordable, option if she doesn’t get into Chapel Hill. D24 loves the idea of a school near the beach, and possible honors college. Big drawback is neuroscience is a minor only. @CollegeNerd67 's idea of starting there then transferring to UNC broadens the appeal of this option.