It’s important to know that the estrogen must be taken with progesterone. The testosterone is optional and something to discuss individually with your doctor. The estradiol cream can be used individually and is used, shall we diplomatically say, internally, to prevent UTIs, etc., but the oral or estrogen patch has to be taken with progesterone. Unchallenged estrogen (meaning taking that estrogen without progesterone) may increase a risk of cancer. Maybe this has changed, but that was my understanding last I heard.
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