How bad does one C+ junior year look?

If you’re not going into STEM, you’re fine. FWIW, a friend of mine got 2 C’s in AP Physics and still ended up going to his first choice uni for econ (or poli sci, can’t remember). Now if you were applying to CalTech/MIT/GT under a Bio-Eng major, that’d be a different story.

Also, the AP test for Biology is really not that bad, especially with tests getting watered down this year, I wouldn’t be too worried about that