Another tangentially-related example of how the two schools differ in the ideals that they might be looking for in their students:
During the high school protests across the county in the wake of the Parkland shooting last year, Harvard and other elite colleges put out a statement that candidates for admission wouldn’t be penalized for skipping school to participate, even if your high school docked you. In contrast, University of Chicago informed candidates for admission that they were absolutely free to participate in demonstrations and protests; however, they were still expected to comply with their high school’s requirements for completion of work, attendance and so forth.
So - that C in APUSH because you were too busy attending rallies in the spring of 2018 to complete your assignments presumably wouldn’t be held against you in an admission decision with Harvard. UChicago - different story.