My sons started out the same way but have realized that being far away isn’t as glamorous as they thought. It’s nice to have a support system close by if needed. My parents were less than an hour away for undergrad. I saw them at holidays and a few times if I was sick or needed a home cooked meal but not often.
Pitt, Ohio State, and Case Western would be obvious choices for pre med. Pitt has a guaranteed med school admission program. He would probably be eligible for some top scholarships.
https://oafa.pitt.edu/explore/guaranteed-admissions-programs/medicine-gap/