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<p>Actually, it highly depends on the professor and their teaching style. I took an introductory bio series, which usually consists a maximum of 500 students, with a professor who was really eager in student participation and always asked thought-provoking questions (like “why do you think…” ) for students to answer, and this professor would come up to you and hold her mic out to the student answering the question so everyone could hear. My former O-chem professor frequently stopped after every major topic to ask “how are we doing?”, which is an opportunity for people to ask questions. So it’s not always the case that large universities and a high faculty:student ratio equals not being able to ask questions in class.</p>