I first applaud all the parents on this thread for having such academically well prepared students, and spending a great deal of time on the search/selection process for application.
DDs may have no idea now if they will be pursuing graduate or professional school. How set one is on her degree plan, and what the other daughter may eventually pursue and what would be the best place for her to find what she wants to pursue. If one or the other decides their school based some on geographic preference or wanting to be near (or at same school as other twin).
IMHO I would pile on more ‘safeties’ where the cost of attendance, due to merit will be reasonable for what is being pursued.
Buyer’s remorse comes to mind if one ends up paying a lot for UG and the student/family is disappointed in what happens at that school.
Sounds like a lot of schools were visited. Student thinking can be much different as their senior year is progressing.
My two finished UG and did not pursue graduate school, although both had the capability to do so.
Know many students who chose a school for BME and then found it wasn’t what they thought it would be. Some stayed in engineering discipline or other STEM. A classmate of DD2 complete UG BME degree in 2016 and needed to go on to Master’s - in part due to job market. When she finished her Master’s she was searching hard for a job as many positions wanted PhD and she had academic fatigue. She did get a position, but it was a process.
Best of luck as the school determination continues with acceptances and final decisions.