At our feederish HS, my male S24 was “allowed” to view Vassar as a softer reach/harder target in RD due to his gender, and he was in fact accepted with qualifications that appear pretty similar to lilyesh’s. So they both might have been right in that zone where it can matter, and I agree the OP might well be too.
That said, the practical significance of all this is somewhat limited in my view, other than I think if you generally like colleges like Vassar and this is a bonus reason to keep Vassar specifically on your final application list, sure, why not?
As for the major thing, I am dubious it plays much part, if any, at colleges where you are going to explore and choose your major later anyway. I also doubt a STEM major, for a male applicant in particular, would be helpful even if Admissions was occasionally intrigued by some less popular intended majors.
Again, no way of knowing what really mattered, but S24’s HS college counselor (a very experienced one who had worked in Admissions herself) seemed to think his interest in Biology was pretty useless (she didn’t say it that way, but that was my blunt takeaway), but his interest in Latin, Classics, and eventually Philosophy/Ethics was a lot more interesting.