Is it correct to assume that the student is a high school student taking college math courses at UPenn?
https://www.math.upenn.edu/ugrad/CourseDescrPage.html are the course descriptions, although UPenn names them differently.
103 Introduction to calculus = “calculus 1” at most colleges, or high school calculus AB
104 Calculus, part I = “calculus 2” at most colleges, or high school calculus BC
114 Calculus, part II = “calculus 3” or “multivariable calculus” at most colleges
240 Calculus, part III = “linear algebra and differential equations” at most colleges
Multivariable calculus is usually not needed for biology majors. It is usually taken by math, statistics, pre-PhD economics, physical science, and engineering majors. However, it is not generally considered much more work or much more difficult than the previous calculus course (though it can be easier or harder for some specific students).
For biology majors, statistics is probably more useful. It looks like UPenn offers either very low level statistics courses (101/102 or 111/112, non-calculus-based, probably like high school AP statistics), or very high level in-depth multivariable-calculus-based statistics courses (430/431, requires MATH 114):
https://statistics.wharton.upenn.edu/programs/undergraduate/course-descriptions/
There is also a statistics course in the biology department (BIOL 446) that is hard to find a description for.