<p>alh,</p>
<p>You will not run out of pharma-bashing “studies” and op-eds out on the internet. You could post them all day! It is its own cottage industry – a terrific way to get a first-author paper published by someone trying to get tenure at a college. Too bad that when actually examined with some objectivity and econometrics most of the bashing of pharma becomes pretty lame. It’s a for-profit industry, certainly. Just that status seems to make many people’s blood boil! It’s fine if their dermatologist is bringing home a million a year to treat their kid’s acne though. lol</p>
<p>Anyway – regarding the “cost” of developing a new drug. The main omission your studies have is that they only look at successfully launched drugs – the ones that make it all the way through animal, small human trial, big human trial, then the FDA gauntlet. And even if we only look at those, the studies of the cost that actually have some grounding in reality show that they have been more underestimated, than overestimated. Why? Well, do you really think a drug company wants to tell Wall St that their costs of R&D are gigantic?? What do you think that does to the share price? No, they like to be seen as if they are controlling costs, developing drugs efficiently and operating with a good business model.</p>
<p>But it’s critical to understand that only 1 out of 10 candidate compounds ever makes it to market. Many cost a billion to develop and then never get final FDA approval. Others cost a billion but never get prescribed because by the time they are approved they are already obsolete or face generic competition. If you factor in all the misfires then the actual cost of bringing one successful drug to market is truly mind-boggling.</p>
<p>It’s pretty much like wildcat oil drilling. Massive investments to try to develop a new therapy that has a bout a 1 in 10 chance ever being prescribed.</p>
<p>[Healthcare</a> Economist Cost of drug development: $1 billion](<a href=“http://healthcare-economist.com/2010/02/16/cost-of-drug-development-1-billion/]Healthcare”>Cost of drug development: $1 billion – Healthcare Economist)</p>
<p>Then the stuff on the lobbying. Well, if you want to look at the companies paying lobbyists the most you’re not going to see a lot of pharma –</p>
<p>[Business</a> News, Stock Quotes, Investment Advice - DailyFinance](<a href=“Stock Portfolio & Tracker - Yahoo Finance”>Stock Portfolio & Tracker - Yahoo Finance)</p>
<p>And where it really gets interesting is to look at the top lobbying companies and what they pay in federal taxes –
[30</a> Major U.S. Corporations Paid More to Lobby Congress Than Income Taxes, 2008-2010 - International Business Times](<a href=“http://www.ibtimes.com/articles/264481/20111209/30-major-u-s-corporations-paid-lobby.htm]30”>30 Major U.S. Corporations Paid More to Lobby Congress Than Income Taxes, 2008-2010)</p>
<p>Now if you aggregate all of pharma – including generic companies, btw!!, which of course work against the big bad pharma, you’ll get a big number. But what other industries have government programs (Medicare, Medicaid) as their biggest customers? And what other industries can’t sell a product at all without the govt (FDA) “allowing” them to?</p>
<p>So is it really that outrageous that pharma as an industry would be very engaged in legislation that directly affects (1) whether they can sell a drug, and (2) what price they will be allowed to charge for that drug. </p>
<p>Do you really think that GE has the same valid government engagement as Johnson & Johnson? Of course not. GE is lobbying the government to enact loopholes to enable them to pay no taxes. Johnson & Johnson is lobbying the government to enable Medicare patients with breast cancer to get the newest available therapies. Such villains!!</p>
<p>But hey, keep the pharma-bashing going. It’s fun and you have a lot of company!</p>