my diagnosis of advanced cancer: how to help my kids

<p>based on PM’s I am getting, there are lurkers who are dealing with cancer. So, I would like to just share some additional information about gauging the effectiveness of the treatment.</p>

<p>The scans. CT scan shows the presence of mass. PET scan tells you whether any mass is malignant or not (malignant cells light up). </p>

<p>Normally, they use CT scan to gauge the effectiveness of the treatment. if the tumor shrinks, great. If it grows, well the treatment is not working. This works fine for most patients. In most cases, tumors start to shrink when the treatment is working. </p>

<p>Well, I am an exception case. When the treatment is working, my tumors go metabolically inactive (meaning starting to die), but the tumor size does not change initially. The dead cells just sit there, keeping the same mass and size. In this case, CT scan will tell you that the treatment is at best able to keep the tumors stable, but not working beyond that. However, if you take a PET scan, it will show that tumors were dying.</p>

<p>Well, I was booted off of the trial because they deemed the treatment protocol a failure based on the CT scan results. The PET scan I insisted on gave me clear evidence that I was right all along. It was pretty dramatic. Several inch long “new” tumors that showed on the CT scan were dark (meaning dead) - these tumors were the reason why I was booted off of the trial. One tumor lost half of the value (brightness, so to speak: meaning they are half as active as before). Another one was barely on the threshold of “malignancy”. </p>

<p>The PET scan clearly showed that the clinical trial protocol was working very well for me. </p>

<p>I am not too sorry that I was booted off of it since the new treatment, I think, is also working based on my cancer-O-meter. However, I think it’s a shame that the clinical data will consider me as “failed case” - I think their new drug and what not is actually effective, and can help other women. It’s a shame that my data, which should have been a resounding success - is being registered as a “failure” case. </p>

<p>For those out there who are going through this journey, information is power. Self advocacy can mean night and day difference.</p>

<p>I am a researcher at heart. I turned my medical condition into a research project. An important part of research is data gathering. I requested all sorts of items to be added to my regular blood tests to see what correlates with the cancer activities and what trends there are. Lo and behold. I am starting to see a very clear pattern and trends. </p>

<p>My doctor has a lot of patients to take care of. I have only one: ME. I can analyze the data, and see the trends and patterns that the doctors miss. For instance, thyroid hormone level has 100% correlation with the cancer activities for me. The trend is so amazingly clear and flamboyantly obvious, I am wondering why oncologists do not routinely add that test to the blood test panel. It’s an amazing diagnostic tool for me. I also learned that cancer blood marker test performed at different labs using the same technique can show 20-30% fluctuation. So much for all the meta analysis studies that discuss prognostic value of nadir cancer blood marker at the conclusion of the chemo therapy.</p>

<p>I am planning to continue to gather as much data as possible. Without all this data, I would have just accepted the doctor’s verdict this time around, and not have come up with the idea of doing PET scan. It’s not a ****ing match of who is right or who is wrong. The worst nightmare for an advanced stage cancer patient is to run out of treatment options. I just rescued a very good drug from a trash can of “ineffective drugs that don’t work for this patient”. It’s important for me to know what kind of treatment actually worked and what didn’t so that I know what options I have going forward.</p>

<p>Sunriseeast…I don’t understand one thing…</p>

<p>You were booted off the trial. Can you still get access to the experimental drug since it was working?</p>

<p>Good luck to you…I wish you the best.</p>

<p>dstark,</p>

<p>The experimental drug is ONLY available on trial since it does not have an FDA approval. The other drug, which is NOT experimental, is also only available on trial until further notice, not because of the approval issue, but because it’s one of those cancer drugs that are no longer available due to the shameful cancer drug shortage scandal (yes, I call this phenomenon a scandal).</p>

<p>In fact this drug (Doxil) is considered a best defense for women recurring so soon after the initial front line therapy, and it was the reason why I chose to participate in this trial since it was the only way to get it.</p>

<p>It really is a scandal that a life saving drug like this became somehow “unavailable” through whatever shenanigan that caused the shortage.</p>

<p>I think the new treatment I am on is also working so it wasn’t too bad that I was booted off of the trial. However, if it had not been the case, that means that I was booted off of the trial that was a life saver without any workable substitute for a wrong reasons… When I look at this this way, it really is scary - how life and death matters are decided haphazardly like this…</p>

<p>Yes…when I read your last paragraph…it is tragic…we are talking life and death…</p>

<p>I am glad to read that your new therapy is working.</p>

<p>You are an inspiration.</p>

<p>Cancer Warrior for sure …</p>

<p>I agree. </p>

<p>I see your book in 2 parts: 1) your self reflection and wonderful stories, then 2) your data and research. Oncologists will benefit from both!</p>

<p>so, the new blood test came back with the cancer antigen number. I mentioned in an earlier post that the PET scan showed that I was right all along: the clinical trial treatment I was booted off of was actually working. This new blood test is a gauge of whether the treatment I was put on after I flunked out of the clinical trial is working or not.</p>

<p>My cancer meter told me that it was working, but I was never sure.</p>

<p>Well, GOOD NEWS. The latest blood test shows that this new treatment is also working for sure. The cancer blood marker is dropping like a rock. In fact, during my previous front line therapy earlier this year, it did not drop this fast. On the book, the number is already within a normal range - but I don’t think I am done yet. </p>

<p>I AM SO RELIEVED. I beat the 10 to 1 odds! </p>

<p>On top of that, can you imagine how I would be feeling if this new treatment was not working, after I was booted off of the protocol that was proven to be actually effective for me?</p>

<p>Last 4-5 weeks was very scary for me… When they deemed the clinical protocol a failure, I could easily see the familiar pattern: women with my diagnosis failing one treatment after another is sadly a common occurrence. After all, five year survival odds with my diagnosis is in single digit. How you do think that number remains so low if all of us keep on living…</p>

<p>Now, I know that the the previous treatment was working (I proved it by insisting on a different kind of scan). Now, this new treatment is also shown to be working. So, during the course of 4 weeks I was transformed from a patient who keeps failing on new treatments into a patient who responds to any kind of treatment that they throw in.</p>

<p>Grim statistics associated with my diagnosis becomes a reality when there is no more arrows in the quiver. I feel that my quiver is still full of usable arrows. I am so relieved today.</p>

<p>Thank you so much for your kind and generosity. It’s been exactly 12 months since I started this journey. You all have been my biggest leader leading team. I am so grateful. Thank you again from the bottom of my heart.</p>

<p>Yipee! I am so very happy for you!!!</p>

<p>that is awesome news!</p>

<p>Celebrate!</p>

<p>That’s wonderful, sunrise! I can’t believe it’s been a year. </p>

<p>Before I signed in to post, there was a huge ad for Memorial Sloan Kettering at the top of the page!</p>

<p>Sunrise – Have you considered writing to the researcher heading the study you were kicked out of and providing this information – not to get back into the study, because that would (probably) be a violation of the research design – but to at least get them thinking that they may want to consider a different assessment for whether or not the drug(s) are working for those whose CAT scans seem to indicate that it might not be?</p>

<p>Wonderful!</p>

<p>sunriseeast-you ROCK! Congratulations on this great news! May you go from strength to strength!</p>

<p>So happy for you, sunrise! Don’t think too much about the 5-year statistics. Those are from before all these new treatments… old worthless data… you are in a new era with new treatments.</p>

<p>I love good news! Soooooo happy for you, Sunrise!!!</p>

<p>Sunriseeast…I am very happy for you…</p>

<p>can you hear your home crowd cheering?</p>

<p>I am so happy to hear your most wonderful news!</p>

<p>Wonderful news!!!</p>