I have seasonal affective disorder which manifests mainly as depression but it also brings on confusion and anxiety connected to the brain fog. When I was younger, it was much, much worse.
I have found that with age, knowledge, and an arsenal of strategies, my need for seasonal medication has diminished to the point where I haven’t taken it in years.
So I believe emotional and physical maturity plus body changes plus awareness/strategies can alter one’s need for medication—depending on the condition.