For MLS vs LSM:
You can handily do Pre-Med from either (MLS slightly more geared towards it i guess because of the submatriculation aspect) but if you are NOT considering business then do MLS. LSM is only for people interested in possibly doing/ combining both and it might be harder to fit in all those premed requirements.
M&T kids rarely go down pre-med route and i’d think its very hard to fit in the premed requirements on top of your engineering+business dual degree courses.