It looks like a year of DE Calc is the right choice for you since it allows you to take Calculus while not being overwhelming (as it sounds AP Calc AB, as taught at your school, would be). And, yes, a great teacher is always the right choice.
Wrt Spanish, was the Middle School class Spanish 1 or Spanish 1a (with 1b in 9th grade)? In Other words, did you reach Spanish 3?
DE English, DE A&P, AP Stats, AP Chem, AP Psych, would be a strong schedule for senior year.
Is there a way for you to volunteer or find experience in a clinical setting?
Note that as a PA the ability to speak Spanish fluently (ie., quite a few levels above AP) will be very valuable. Italian is a great language but not as useful. “Self teaching” doesn’t count for admissions although it can help with Placement, ie., help you manage to not forget any Spanish between the end of 10th grade and the beginning of college when you take the placement test that determines how many semesters you need to take in college (completing a minor is going to be very useful to you - you can look at colleges you’re interested in, see if their Spanish dept. offers “Spanish for the Health professions”, or email them to ask).
Chatham (in Pittsburgh), DeSales and Duquesne also in PA, Daemen (in NYS), Quinnipiac, Stockton have direct-entry I think, but run the NPCs since none of them “meet need”. Some PASSHE schools have a PA program but I don’t think they have guaranteed direct entry, check though.