Yes you’ve made it harder for yourself, but don’t give up hope. Both S’s GPAs were below 3.2 at end of freshman year. He’s an MD and will start his last year of residency in a few weeks. Try to stop worrying and try ASAP (along with your school’s student services (counselors, tutors) to identify the reasons for the disparity between your hard work and grades. What went wrong, what could you do better (eg, stay more on top of material, not cram, seek help earlier in term if you’re getting lost, not eliminate social life but have a better balance between social and academics, read all req readings, find old tests from any given prof to study, learn to take better notes, etc). Grades must come up soon as every grade below an A (especially in science courses) will be to your detriment. You may have to throttle back on research and other ECs as raising your grades is job number one. This could mean you not apply to med school until after graduating. You might rethink need to take 5-6 courses every semester as med schools don’t care so much about rigor. Good luck.