<p>Threeofthree- I wish I could help but I don’t know of anyone personally who has used collagen 2. I do know that the pain indicates inflammation which eventually will cause permanent joint damage. I was happy that my son did not have to stay on MtX for long. We saw no results from it and his Dr. was more worried about long term side effects from it than from the biologics. However, she could not get Enbrel approved until he had at least tried MtX. I do know that the biologics have, for now, prevented further damage to my son’s joints. They do not repair previous damage but have allowed him to live a more normal life. I’m sorry that you are having to deal with this as I think in some ways, dealing with possible effects of the drugs is as scary as the disease. </p>