<p>Thanks Lady Lorna - I’m sure the Dr will do xrays and determine the next step but he has mentioned that if the flares become more frequent/severe the MTX is usually the next step. I will certainly tell the Dr about my concerns, I just didn’t get the impression when I spoke with him at the beginning of this adventure that there were many options with the excellent results from MTX without the toxicity. I was hopeful that perhaps the Type 2 Collagen could work with the Plaquenil to stave off the frequency and severity of the flares and not have to go w/ the toxic stuff this early. I’ll keep your information handy and ask him about other products. BTW thank heavens for Prednisone - wow that stuff is good!</p>