<p>You can lock checked luggage (if it has the little loopy things where the zippers meet) with approved combination locks that TSA can open. We invested in a few of those, and set 'em all to the same combination so anyone in the family can open them. So when we leave a hotel room that does not have a safe, we lock things we don’t take with us (like D’s laptop) inside. As someone mentioned above, they could take the suitcase, but it is not as easy.</p>