I didn’t quite understand if the DE class will be in addition to your required jr/sr schedule or if you will be replacing one of those classes. My recommendation, if this is the first time in a college classroom, is to take a class in your strongest area. It is difficult adjusting and you definitely want an A in your DE class if possible. I think I would avoid lab classes because they take up so much time, and your schedule is already packed.
I saw Spelman, and if you are considering Atlanta, look seriously at the Honors College at Georgia State University. Take the time to visit if you visit Spelman. It is just a few years old and very impressive. With your scores, you are likely to be in the running for a full Presidential Scholarship. Honors Colleges have a small feel inside a large university.